Further genetic and biochemical studies of ASL3 will be required to gain insight into its detailed function.
Although available evidence implicates SNCA in synaptic vesicle recycling and neurotransmitter release in interaction with the vesicle co-chaperone cysteine-string protein-α (CSPα) [1], [2], its detailed function is not yet understood.
CD83 expressed on dendritic cells delivers costimulatory signals to T cells for activation [ 43], and CD83 expressed on T cells has been hypothesized to be involved in T-cell activation with its detailed function yet to be defined [ 41].
However, its detailed functions and mechanism of action as a whole remain unclear.
Several studies have reported that TLR4 and TLR9 may regulate disease severity of EAE, but the detailed functions of TLRs during MS/EAE are still controversial (Kerfoot et al, 2004; Marta et al, 2008; Prinz et al, 2006).
However, the detailed function of Traf6 and its underlying mechanism still remains unclear, especially its effect on the progression of mild AP to severe AP.
Deciphering the up-regulated genes among the SCOP general categories into detailed functions uncovered three key SCOP detailed function categories, namely the redox detailed function category in metabolism, signal transduction and kinases/phosphatases in regulation, and proteases in intra-cellular processes.
For each candidate gene, we annotated the specific PCW synthesis stages in which it is involved and predicted the detailed function.
In future investigations it will be interesting to determine the detailed function of this enzyme in the salt acclimation in rice to further advance the understanding of adaptive cellular mechanisms in salt-stressed plants.
Until now, little is known about the detailed function of this protein, despite it being highly expressed on B-lymphocytes, natural killer (NK) and dendritic cells (DC) (Skinningsrud et al. 2008).
