Anesthesia-related effects can be avoided by studies in awake animals, but this is problematic from the animal welfare point of view as head fixation or restraint induces stress, which can greatly influence the results of brain studies.
Imam: Well, I think it is problematic from the view of tradition, but the issue is not how Muslims should be buried, the issue is how should bin Laden -- a very unique individual -- be buried.
As potential employers of university graduates, businesses are end users of test scores, but very little is known about how they actually use those scores, which is problematic from a validity and a policy perspective.
"Cyberwar is problematic from the point of view of the laws of war," said Jack L. Goldsmith, a professor at Harvard Law School.
Some feminists have argued that philosophy of language is problematic from a feminist point of view.
It is recognized that the absence of a standard load model causes design outcomes varying from agency to agency, which is problematic from performance and reliability standpoints.
Requiring a direct link between online and 'real world' identities is problematic from a privacy perspective, because they allow profiling of users (Benevenuto et al. 2012).
Grosz argues that architecture is problematic from a feminist perspective because it largely has ignored questions of sexual and racial differences.
Including intermediary inputs such as skills or training in the earnings or employment equation is problematic from an empirical viewpoint because skills and training are endogenous variables.
In addition, the existing DEM is problematic from the viewpoint of industrial applications, since complexly shaped dies might not be modeled by existing technologies.
