Sentence examples for but increased activation of from inspiring English sources

TLR4-dificiency was also associated with decreased phosphorylation of PI-3K and AKT, but increased activation of STAT3.

Following sham, adults with autism relative to controls had reduced activation in key inhibitory regions of inferior frontal cortex and thalamus, but increased activation of caudate and cerebellum.

Interestingly, as evidenced in a knock-in mouse model of LS, as well as in cell lines derived from individuals with LS, LS mutations seem to result in blocked activation of MAPK but increased activation of AKT downstream of receptor tyrosine kinases (Edouard et al., 2010; Marin et al., 2011).

Furthermore, treatment with siRIP3 did not alter the activation of caspase-8, but instead increased activation of caspase-9 and promoted endonuclease G translocation into OHC nuclei.

Such changes could be responsible for the diabetic phenotype under the control of the gut microbiota, and may even explain the increased inflammatory tone observed in HFD-D mice via the slight but significant increased activation of NF-κB and mTOR pathways which are upregulated during metabolic diseases.

In contrast, knockdown of FLIP did not inhibit, but even slightly, increased activation of NF- κB by TRAIL, as it has been described before.

In this study, the results demonstrated that Everolimus treatment inhibited p-S6, but led to increased activation of p-AKT (Fig.  4b).

The downstream effect of increased PI3K is increased activation of the AKT pathway.

For the right-sided resections at 3 months there was no support for the importance of the right hippocampal remnant but we did observe increased activation of the ipsilateral superior parietal lobe.

The R952Q variant of LRP8 increased activation of p38 mitogen-activated protein kinase by oxidized low-density lipoprotein.

The molecular basis of trastuzumab resistance are still obscure, but there is evidence that increased activation of other growth factor signaling systems may contribute to this process [ 28].