KRAS codon 13 mutation was associated with a significantly reduced CSS in women, but not in men in unadjusted, but not in adjusted analysis.
However, in microsatellite stable (MSS), but not in MSI tumours, an adverse prognostic impact of BRAF mutation was observed in unadjusted, but not in adjusted analysis.
Overall, mutation in KRAS codon 13, but not codon 12, was associated with a significantly reduced CSS in unadjusted, but not in adjusted analysis, and BRAF mutation did not significantly affect survival.
In the entire cohort, a similar survival was seen for patients with KRAS wild-type and codon 12-mutated tumours, while patients with tumours harbouring a KRAS codon 13 mutation had a significantly reduced CSS (HR = 1.94; 95% CI = 1.18 3.19) in unadjusted, but not in adjusted analysis.
Associations were weaker for ADBV but remained significant in adjusted analysis for the DXA measures of percentage fat mass and A G ratio.
Height was significantly positively associated with %DBV in adjusted analysis, but it was not associated with ADBV in adjusted or unadjusted analysis.
Although the effect did not remain significant in adjusted analysis but it corresponded with previous studies that report higher risk of childhood under-nutrition with smoking [ 51- 53].
Gender effects were not found in adjusted analysis, but as the study wasn't powered to stratify by gender this observation should be interpreted with caution (data not shown).
This innovative approach allowed not only a quantification of the association between the two dimensions of SEP and health-seeking behaviour outcomes in adjusted analysis, but also an assessment of their relative importance as drivers of inequalities.
