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In other words, when genetic perturbation by a mutation has minor effect but have large effects in combination with defects of other genes (i.e., synthetic lethal or sick and therefore robust), the gene shows resilience to environmental stress (environmental robustness) and/or stochastic change (stochastic robustness).
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It is not only a large political force in its own right but has large effects on all around it.
That only one common variant came out of this large sample study indicates that "there probably are many more that contribute to autism, but none have large effects," said Dan Arking, assistant professor of medicine at Johns Hopkins McKusick-Nathanss Institute of Genetic Medicine.
Correlations assumed in multi-country evaluation had very little effect on convergence rate but can have large effects on the direct genomic values (DGV), particularly on scales where large proportions of bulls are foreign and have converted information.
But they can have large effects on muscles and joints, often making muscles work as much as 50percentt harder for the same movement and increasing stress on joints by a similar amount.
There is a potential problem in that these compounds can bind to serum proteins, but this may not have large effects at low concentrations [34] and we included serum (bovine serum albumin) in our chemotaxis experiments to mimic this effect.
The comparison of Models 4 and 5, which included the same traits, was slightly in favor of Model 4 in four out of the five subsets of data, suggesting that assuming no genetic variance in runt growth might be desirable, but this did not have large effects on the predictive ability of the model.
Another kind of headache for geneticists comes from gene variants that do have large effects but that are unique to you or to some tiny fraction of humanity.
This also includes rare variants that have large effects but explain a small proportion of the variance [ 13, 14].
But even weak forces can have large effects when they act over long periods, and accumulation of core uptake sequences has dramatically modified their associated proteomes, more than doubling the frequencies of many of the tripeptides they can encode (fig. 1).
" Can Small Incentives Have Large Effects?
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