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But genes implicated in GWAS often account for only a small fraction of the heritable variation of a phenotype (Hindorff et al. 2009b; Manolio et al. 2009; Mccarthy et al. 2008).
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Predicted target genes include transcription factors but also genes implicated in various metabolic processes and in stress defense.
Three of these studies identified several hundred differentially transcribed candidates from which genes previously identified as implicated in aggressive behaviour were conspicuously missing but in which genes implicated in functions such as energy metabolism, protein synthesis and even muscular contraction were over-represented [23] [25].
The phylogenetic affiliations of different functional subsystems showed strong biases: Most but not all genes implicated in the core translational apparatus tended to group Aquificae with Thermotogae, whereas a wide range of metabolic and cellular processes strongly supported the link between Aquificae and Epsilonproteobacteria.
Some, but not all, of the genes implicated in ASD overlap with those implicated in MR [45] [48].
The functional importance of these GWAS findings remains to be tested in disease models, but it is becoming clear that genes implicated in AD development form functionally related groups.
In filamentous fungi genes implicated in outer chain formation are present, but their function is unclear.
"The relaxation response appears to turn off genes implicated in inflammation, and the stress response itself," says Dr. Mehta.
Two-hybrid protein-protein interaction screens were carried out for S. cerevisiae genes implicated in mRNA splicing and microtubule assembly.
Dr. Winkelmann said the three genes implicated in her study had come as a complete surprise because they had never been suspected of involvement in the syndrome.
A consensus sequence for Arc binding identifies several additional partners that include genes implicated in schizophrenia.
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