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U1i inhibitors can be potent suppressors of HIV-1 production in transient assays but further optimization of this antiviral approach is needed.
Bioreactor cultures were very rapid (peak activity at 29 h), but further optimization of the process efficiency will be carried out.
With the development of the PHH MPCC system, it is now possible to achieve robust liver-stage malaria infection in vitro (March et al., 2013), but further optimization of infection efficiency remains advantageous.
Currently, 26 priority species have been selected for surveillance sampling in Alaska (Ip et al. 2008), but further optimization of this list, and timing of sampling, could be based on analysis of LPAI viral genetics as summarized in this study.
To date, no small molecules have been developed that directly control the expression of Fe-S clusters, but further optimization of a quantitative system for measurement of Fe-S levels (Fig 2) may hold the key for high-throughput drug screening.
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Thus, further implementation of the possibilities offered by CBM33s and GH61s may not only affect the costs of the enzymatic saccharification step but may also direct further optimization of the preceding pretreatment step and process design in general.
(xli) Further optimization of the cyclooctyne reagents remains necessary to obtain the optimal balance of reactivity and pharmacokinetic properties.
Further optimization of AdoMet analogue synthesis is certainly possible, but any methionine derivatives would be administered as prodrugs that must be converted in vivo into methyl donor molecules.
Further optimization of all the parameters will be necessary to devise an optimal procedure for neighborhood size selection.
Further optimization of the DFB grating will likely allow lower lasing thresholds and facilitate LED pumping of membrane lasers.
Further optimization of this method should allow rapid and scalable genome engineering in human cells.
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