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72 73 Evidence from observational studies suggests that changing the built environment has the potential to influence cycling behaviour, 64 but few data from controlled intervention studies are currently available to confirm this.

The combination of RAD001 with exemestane was recently found, in the BOLERO-2 trial [ 25], to be more effective than exemestane alone for the treatment of advanced BC after initial treatment with a nonsteroidal AI, but few data from laboratory models provide a mechanistic explanation.

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These are well described in patients with cardiac disease and in healthy subjects, but few data exist from ICU patients.

Epidemiology and clinical outcomes are known to vary with socio-economic background, but few data are available from developing countries, where the overall burden of infectious diseases is frequently high.

There is a lot of experience gained from soil and water/sediment simulation tests conducted at 20 °C (or room temperature), in particular for PPP, but only few data from testing at lower temperatures.

Background: Manganese neurotoxicity is well documented in individuals occupationally exposed to airborne particulates, but few data are available on risks from drinking-water exposure.

The prevalence of CHD is also comparatively high, [ 11- 14] but few data are available on incidence from population studies [ 15, 16].

HMGB1 has been detected in the blood of patients with various conditions, but few data are available on specimen collected from sites of local inflammation or cell damage.

Apelin is emerging as an important regulator of cardiovascular homeostasis but, at present, few data from humans are available and further studies are necessary to better define its role in cardiovascular pathophysiology.

Growing evidence suggests high levels of comorbidity between hypertension and mental illness but there are few data from low- and middle-income countries.

FFP is widely used, but there are few data from prospective studies describing patterns of plasma use in critical care.

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