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If a company invests millions in research but fails to develop a vaccine that meets the contract's specifications, no money would change hands.
The playwright frequently offers hints about her characters in the play's script, but fails to develop them further or explain them clearly to the audience.
The bfl1 mutant shows normal differentiation of the primary rachis-branches leading to initial spikelet meristem (bract-like structure equivalent to rudimentary glumes) formation but fails to develop empty glumes and florets.
Using a stereotaxic injection approach (Clavaguera et al., 2009), a donor brain extract was derived from 6-month-old NFT-forming P301S mice (Allen et al., 2002) and injected into brains of 3-month-old ALZ17 mice (Probst et al., 2000; Götz and Nitsch, 2001), a (wild-type) tau transgenic strain, that develops a tau-associated amyotrophy, but fails to develop NFTs (Clavaguera et al., 2009).
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Alongside these findings, animal studies demonstrate that IL-21R deficient mice have normal T-cell and NK cell development but fail to develop spontaneous autoimmune disease suggesting that IL-21 plays a vital role in the development of autoimmune disease in rodents.
Mortality of transgenics in the absence of tetracycline is strongly stage-specific, being primarily around the pupal stage (L4-pupae and pupae-adult; most affected individuals started to pupate but failed to develop beyond the earliest stages of pupal development).
Conversely, modern philosophy, beginning with Descartes, appreciated the value of subjectivity as a philosophical starting point but failed to develop an adequate notion of objective truth.
It had even received tips years ago that Mr. Madoff was running a Ponzi scheme but failed to develop a case against him.
The militant, Mujahid Asari-Dokubu, was jailed after he declared war against the government over corrupt practices that stripped the Niger Delta of its oil wealth but failed to develop it, making the Niger Delta one of the poorest regions in Africa's top oil producer.
For the past decade, Sears has been run by Edward S. Lampert, a hedge fund manager who sold off many of the company's valuable properties and brands but failed to develop a strategy for winning back consumers who were increasingly doing their shopping online.
For years biotech firms had tried but failed to develop drugs for psoriasis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com