In his book "How Many Friends Does One Person Need?" Professor Dunbar stands by his number, acknowledging that digital resources help us keep in touch but fail to substitute for face-to-face relationships with loved ones who are sources of mutual support in a flesh-and-blood world.
Noteworthy is the observation that in these fos mice another component of the AP-1 family, Fra-1, rescues c-Fos functions in the growth process when its expression is controlled by the c-Fos promoter but fails to substitute c-Fos in inducing expression of target genes in fos fibroblasts [27].
The excess silicate species that failed to substitute into HA lattice, polymerized on the surface of the prepared HA grains.
Both devazepide and L-365,260 failed to substitute for the discriminative stimulus properties of CDP, and CCK-8s failed to block its stimulus effects.
Despite this overexpression, OsINV2 failed to substitute for the key physiological roles of OsINV3 in maintaining the hexose-to-sucrose ratios (Fig. 6i).
Further increases in M-CSF concentration in culture, up to 120 ng/mL, failed to substitute for the anti-apoptotic action of TNF-α (results not shown).
Interestingly, BLM appears to be unique in the double HJ dissolution reaction since WRN, RECQ1 and RECQ5 all failed to substitute for BLM [ 17, 19].
Chemical rescue experiments of the mutated tyrosine by addition of low molecular weight phenols failed to substitute for the loss of the pKa of a titratable group or to restore the catalytic activity (data not shown).
In ALS inefficient RNA editing fails to substitute an arginine for a glutamine residue in the GluR2 Q/R site of glutamate AMPA receptors in the spinal motor neurons and is proposed as a mechanism responsible for motor neuron death [18].
