But the essentiality of electricity to modernity is incontrovertible.
The C-terminal domain of dRecQ4 is dispensable for its essentiality, but the rescue efficiency of the truncated protein that lacks the C-terminal is only about 10% compared with the full length dRecQ4 protein.
It is tempting to conflate gene frequency with relative essentiality, but is it valid?
The reason for the modest increase is that there were also 18 additional false positive (iNJ661 gene essentiality, but in vitro gene non-essentiality) results (from 46%to44%4% for the original and expanded objective functions, respectively).
This enrichment would still be statistically significant if only 50% of the subunits of a large complex changed essentiality, but such behavior would not be consistent with the idea of modular essentiality.
More importantly, the impact of extracellularity on mammalian protein evolutionary rate is not only independent from that of gene essentiality but also the greatest among all the factors examined.
Undoubtedly, there is room for debate as to a meaningful definition of essentiality, but it seems that, in general, most genes which are required under rich media conditions will be vital under most other conditions.
As newsroom Latinos continue to decline, Nate is has been a notable exception in 2011 -- not only by keeping his job, but by increasing his essentiality to LATimes online.
Table 5a summarizes the 114 false negative (iNJ661 gene non-essentiality, but in vitro gene essentiality; 50%) results between iNJ661 and the OptGro dataset (for the full results [see Additional file 4]).
The Spearman correlation coefficient for expression divergence and protein divergence was 0.28 (P < 10−) for these genes, but after correction for essentiality, it decreased to 0.24 (P < 10−).
