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Such reduction in NK cytotoxicity seems to stem not due to decrease in quantity but due to functional defect, as the number of NK cells did not seem to differ between patients and control [ 65].
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Therefore, the conservation of the target site is unlikely to be expected under neutral evolution but seems to be due to functional constraints.
This phenomenon does not differentiate between endometriosis and IBS, since not only abdominal pain due to endometriosis, but also gastrointestinal symptoms due to functional bowel diseases have been shown to increase during menstruation [ 19].
There is no discernible phenotype for zpuf-6, but that may be due to functional redundancy because we identified multiple novel secreted proteins similar to zpuf-6 that are also co-expressed in similar cell populations.
Codon usages and gene expression patterns of actin gene copies were highly consistent among the groups because of basic functions needed by the organisms but much diverged within species due to functional diversification.
CD1Nu/Nu (nude mice) present an abnormal hair growth, due to functional follicles but failed hair growth and that is why the skin gives a quick response to any external aggressive factor.
It seems unlikely that the two mitochondria are retained due to functional differentiation, but their genetic redundancy may be related to spatial differentiation.
Similarly, an orthologous gene pair may diverge in sequence beyond detectability, but conserved interaction patterns remain detectable due to functional constraints.
But sometimes both copies are long-term preserved due to functional changes reducing their redundancy and making the loss of one copy disadvantageous [ 14].
Feeding ability in bisected animals was strongly impaired after injury probably due to functional restoration of the gut.
This could be due to other H3K27me3 target genes, or due to functional redundancy with REF6, ELF6 or other possible H3K27me3 demethylases.
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CEO of Professional Science Editing for Scientists @ prosciediting.com