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The earlier demonstration that S599G mutant AR in E006AA cells translocates to the nucleus upon androgenic stimulation, where it effectively binds ARE-containing DNA but does not stimulate transcription of AR target genes, raises the issue of whether the S599G mutation results in a loss-of-function.
Further study revealed that BDDE inhibits the activity of topoisomerase I but does not stimulate the formation of topoisomerase I DNA complex nor intercalate into DNA.
Dip3 functions as a coactivator to stimulate synergistic activation by Dorsal and Twist, but does not stimulate simple activation of promoters containing only Dorsal or only Twist binding sites.
Conversely, 8-pCPT-O-Me-cAMP is selective for EPAC but does not stimulate PKA [31].
Rolipram on its own inhibits PDE IV activity (cAMP breakdown) but does not stimulate cAMP production and as such was not included in this phospho-western result.
FBS (1%) provides enough nourishment to support cell viability but does not stimulate proliferation, while complete medium is known to support cell proliferation.
Similar(50)
In contrast, expression of IRS-2 enhanced IGF-I-stimulated motility, but did not stimulate proliferation.
These immature chondrocytes are metabolically highly active and capable of spontaneous matrix formation, but do not stimulate an immune response.
Vaults are unique adjuvants that induce activation of inflammasomes but do not stimulate through TLR.
High-fat feeding also promoted cholesterol synthesis but did not stimulate VLDL-TG secretion.
The re-expression of mda-5 in these cells roughly doubled their response to the GFP+/− infection, but did not stimulate their response to the DI-H4 infection (fig 1C).
More suggestions(19)
but does not accelerate
but does not encourage
but does not simulate
but does not drag
but does not fear
but does not venerate
but does not become
but does not apply
but does not rise
but does not illuminate
but does not sponsor
but does not tell
but does not end
but does not get
but does not hold
but does not forgive
but does not kiss
but does not promote
but does not understand
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com