CBFβ allosterically enhances Runx DNA binding but does not bind DNA itself.
Note that DNA failed to stimulate the ATPase activity of the ParAR195E mutant, which can still dimerize upon ATP binding, but does not bind DNA (Ptacin et al., 2010; Schofield et al., 2010).
The FnbpA D3 segment contains a well defined 4F1 5F1 binding motif, but does not bind to F3 modules nor does it induce Fn aggregation.
In conclusion, we have developed a cell-permeable peptide (PDP3) that competes with endogenous RVxF-containing PIPs for binding to PP1 in living cells, but does not bind the closely related phosphatase PP2A.
The ruling legally informs but does not bind the state's mining minister when deciding whether to issue mining and environmental licences to the Indian conglomerate.
ChpT adopts a pseudo-HK architecture but does not bind ATP.
Conviction refers to the X, takes a position with regard to X, but does not bind itself to X.
In the presence of splice site B, NL1 binds only to β-Nrxs, but does not bind to α-Nrxs, without SS 4 (Boucard et al., 2005).
However the code is not only voluntary but does not bind signatories to any specific policy steps or processes so it looks like its effectiveness will be as difficult to quantify as its accountability will lack bite.
Additionally, Spider Roll binds to full-length PAK1 in its activated state but does not bind PAK1 when it forms an auto-inhibited conformation that blocks the Spider Roll target site.
From this library, an antibody was isolated (termed AP2), which recognizes the five N-terminal amino acids of fibrin with high affinity (Kd = 44 nM), but does not bind to fibrinogen.
