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Moreover, protamine remained effective after we replaced lumenal Ca2+ with Ba2+, which would prevent "feed through" activation, as Ba2+ can permeate through the channel but does not activate it [42].
These properties include selective action, either in specifically binding to a receptor orthologue, isoform, or subtype; the selective activation of specific hormone response elements; or antagonism, where a ligand competes with the natural hormone for binding to the receptor but does not activate it.
Likewise, skin disease could be effectively replicated by topical cream-based, instead of systemical, application of GW501516 + I3C to the skin, but not by I3C alone (fig. 3h), consistent with the observation that I3C induces transcription of the CYP1A1-driven PPARβ/δ transgene (fig. 2e), but does not activate it.
IP3 binds to the protein, but does not activate it.
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Use the other to find the release mechanism for your four-point seatbelt, but do not activate it immediately.
Outbound, I enter my destination but don't activate it until I'm in unfamiliar territory; inbound, I use it until I recognize where I am.
The researchers screened the molecules, selecting ones that bound tightly to the androgen receptor but didn't activate it.
It said: "While we do download the hotword module on startup, we do not activate it unless you opt in to hotwording".
Indeed, L. pneumophila, an intracellular pathogen which replicates within ER-like vacuoles, cleaves ATF6 but does not activate the PERK-signaling pathway, and it even blocks thapsigargin-induced xbp1 splicing by expression of the two effectors Lgt1 and Lgt2 that glycosylate serine 53 in the elongation factor eEF1A causing protein synthesis inhibition [14].
Our observations, however, suggest that the reason the second Nck SH3 domain alone cannot induce robust actin polymerization is because it recruits but does not activate the WIP N-WASP complex.
BMS189453 binds, but does not activate, the α, β, and γ retinoid receptors [ 23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com