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Sepsis stimulates calpain activity in skeletal muscle by decreasing calpastatin activity but does not activate caspase-3.
Moreover, protamine remained effective after we replaced lumenal Ca2+ with Ba2+, which would prevent "feed through" activation, as Ba2+ can permeate through the channel but does not activate it [42].
This inhibitor has discrete biological effects on endogenous STT3B target proteins such as COX2 but does not activate the cellular unfolded protein response.
Compan, V. et al. Apoptosis-associated speck-like protein containing a CARD forms specks but does not activate caspase-1 in the absence of NLRP3 during macrophage swelling.
So, if a person overdoses on an opioid such as heroin, the naloxone pushes the heroin away and blocks the receptor but does not activate it, so the person can recover from their overdose.
These properties include selective action, either in specifically binding to a receptor orthologue, isoform, or subtype; the selective activation of specific hormone response elements; or antagonism, where a ligand competes with the natural hormone for binding to the receptor but does not activate it.
Similar(35)
Indeed, from our in vitro studies we have shown that lymphocytes enhance Dap12-deficient osteoclast precursor differentiation but do not activate their bone resorbing activity like osteoblasts or stromal cells [15], [16], [19].
They induce BRAF binding to CRAF and CRAF activation, but do not activate MEK ERK signaling.
However, vps36 mutant discs display a very robust neoplastic phenotype, but do not activate the Notch signaling pathway significantly, suggesting that activation of Notch is not required for neoplastic growth in vps36 mutant discs.
As shown in Figure 4c, AP-1 caused a significant increase in the activity of the WT hepcidin promoter but did not activate the AP-1-binding site-mutated hepcidin promoter.
TLR4-L and TLR9-L differentially induced the expansion of mDCs and pDCs (1-3 days), but did not activate DCs.
More suggestions(20)
but does not engage
but does not implement
but does not apply
but does not accelerate
but does not trigger
but does not select
but does not enable
but does not think
but does not promote
but does not prevent
but does not affect
but does not fear
but does not guarantee
but does not venerate
but does not become
but does not rise
but does not tell
but does not get
but does not hold
but does not kiss
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