Sentence examples for but disruption of function from inspiring English sources

Second, that SL interactions, which are defined between two genes when disruption of function of either gene product is viable but disruption of function of both simultaneously results in death, could be screened in genetically amenable model organisms to identify those that may be relevant to the treatment of tumors (Hartwell et al. 1997).

Disruption of function by germline mutations in RET have been associated with several diseases in humans including three related inherited cancers: multiple endocrine neoplasia type IIA (MEN2A), multiple endocrine neoplasia type IIB (MEN2B), and familial medullary thyroid carcinoma (FMTC).

The biology of adolescence is distinctive and provides opportunities for unique actions of toxicants both in terms of disruption of function and disruption of maturation.

Does this mean that a single point mutation can be disfavored for a minor disruption of function?

Genes with multiple PPIs have a higher probability to be essential, just because the deletions of these genes may result in the disruption of function of a larger number of proteins [ 28- 30].

For example, it is possible that the pattern of impaired short-term spatial memory, but spared long-term spatial memory observed in these mice could reflect a nonspecific, but incomplete, disruption of hippocampal function, with short-term memory (or spatial working memory) performance simply being the more sensitive measure of hippocampal function.

Because in this study we found no mutations of p53 but did observe disruption of p53 function in transformed HELF cells, the low levels of arsenite apparently induced the dysfunction of p53 via a signal pathway.

These results indicate that the misdistribution was not due to excessive expression of Dscam[TM1]::GFP, but rather owing to disruption of dynein/dynactin function by dominant-negative Glued.

Therefore, the critical role caspases play in determining cellular fate makes these serine proteases a high-risk target for bacterial pathogens, but when successfully manipulated, disruption of caspase function and caspase-3 in particular, can significantly undermine the host response to infection and can promote dissemination and further bacterial infection.

These include cardiac lesions [ 3], liver histopathology [ 4], compromised immune function [ 5] and disruption of intestinal function [ 6- 9].

These results strongly indicate a causal connection between AHR function, TCDD treatment, and disruption of cardiomyocyte function.