Sentence examples for but direct activation of from inspiring English sources

Epidermal growth factor is known to activate several signalling pathways (Yip et al, 2007), but direct activation of JAK2/STAT3 is rarely observed (Badache and Hynes, 2001).

For insulin, uptake of energy-rich fuels into liver, muscle, and fat will be diminished, but direct activation of local immune cells will still be possible.

All these structures are potential signalling sites for CGRP, where CGRP mediates arterial vasodilatation but not direct activation of trigeminal afferents.

MIF activates ERK and p38 mitogen-activated protein (MAP) kinase, but evidence for direct activation of NF-κB by MIF is lacking.

On the other hand, chronic activation of innate immunity may derive not only from microbial bioproducts [17], [22], but also from direct activation of plasmacytoid dendritic cells (pDC) by HIV [27].

IGF-I increases insulin sensitivity not only through its GH-suppressive effects but also by a direct activation of insulin receptor and IGF-IR [ 37- 39].

Bub1 kinase activity is required for H2A-T120 phosphorylation, but little is known about direct activation of Bub1 kinase by upstream kinases and whether these inputs affect H2A-T210 phosphorylation (Kawashima et al. 2010; Ricke et al. 2012).

The mechanisms by which GLP1, GLP2 and VIP rescue myenteric neurons from mast cell-induced cell death needs further examination but is probably executed by direct activation of neuronal receptors, as in neuronal cultures without the addition of mast cells.

These data indicate that phosphorylation of SIN1 T86 results in a substantial and direct activation of mTORC2 kinase activity.

Although a fraction of cells were insensitive to the siRNA treatment, it may reflect the alternative regulation of myosin II activity through Rock-mediated direct activation of MRLC [36].

It is well known that magnesium can inhibit PTH secretion via the direct activation of CaSR, but this action seems limited in the presence of low Ca levels [ 22].