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Another possible (but difficult to elucidate) explanation might be coevolutionary interactions within SP1 that made a previously deleterious amino acid replacement acceptable.
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The most common mechanism of transfer depends on chloroplast lysis, but it is still difficult to elucidate why the nuclear genome of A. thaliana did not integrate cpDNA with the same patterns as M. truncatula or O. sativa.
In the absence of a detailed analysis of risk factors, the reasons for this increase in prevalence are difficult to elucidate, but we feel that the key message from this study is that no successful efforts are being made in this region to control a parasite of high public health importance.
In Huntington's disease, excitotoxicity has long been regarded as contributing to neuronal loss but the underlying mechanisms have been difficult to elucidate [ 82].
The evolutionary relationships between the members of this large superfamily are complicated and have proved difficult to elucidate [ 19], but understanding of the superfamily in angiosperms (specifically Arabidopsis, rice, and Populus) has improved through the use of genomic history to complement phylogenetic analysis [ 18, 20].
However, the surface states were difficult to elucidate in this study, but it can be said that the layer, which can be removed by alkaline piranha solution, shifted the overall flatband potential to be more negative without changing the bandgap, consistent with the enhanced hydrogen evolution while minimizing the oxygen evolution.
An established association exists between attention deficit hyperactivity disorder (ADHD) and head injury, but the direction of the relation has been difficult to elucidate.
Cross-feeding is an obvious example of a microbial interaction, but some described or implied interactions are more complex and difficult to elucidate.
Histone acetylations are largely considered markers of activity at regulatory elements such as promoters and enhancers, but because of their tendency to co-occur they have been difficult to elucidate the nonredundant roles of these acetylations (Zentner and Henikoff 2013).
The mechanism behind the evolutionary loss of eyes and body pigment is difficult to elucidate, not because it is difficult to explain, but because many of the proposed explanations are difficult to frame into testable hypotheses [ 1, 4, 5].
While the biological mechanism for this outcome may be difficult to elucidate, most people know intuitively that safety and beauty can help cure the ills of modern society, just as an old-fashioned country doctor can heal with a kind touch and a smile.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com