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Both PrP isoforms are encoded by the same gene, exhibit the same amino acid sequence but differ in conformation [3].
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This is strictly caused by the structural conformation of these transporters since both are occluded by the extracellular TMs, but differ in the conformation of intracellular α-helices (closed for XylE and open for GLUT1).
Dekker, J. GC- and AT-rich chromatin domains differ in conformation and histone modification status and are differentially modulated by Rpd3p.
Not only do DNA RNA hybrids differ in conformation from widely targeted DNA and RNA, the low occurrence within biological systems further validates their therapeutic potential.
The two molecules in the asymmetric unit differ in conformation around the substrate binding pocket.
This indicates that the linear and cyclic peptides differ in conformation so that the sites most vulnerable to proteolysis are not common to both peptides.
In addition, unlike decorin, the Slit2 dimermer is not perfectly symmetrical, as the two monomers differ in conformation (r.m.s.d.181Cα=0.45 Å).
Specific individual structural elements of ROCK-I and RhoE that participate at the interface of the complex differ in conformation to their isolated counterparts.
Two other long loops also differ in conformation with respect to the other subclass I FPRs: loop 44 49 that connects β3 with β4 and loop 241 248 located between α10 and β11.
Although we cannot eliminate other possibilities, a logical inference is that they differ in conformation, perhaps because the native enzyme does not fold as well as the synthetic enzyme, which was optimized for E. coli expression.
The asymmetric unit of 1 comprised of two molecules (Z′ = 2), A and B, and that of 2 had three molecules (Z′ = 3), A, B and C. The crystallographically independent molecules in the asymmetric units of 1 and 2 exhibit an essentially similar conformation but differ in terms of molecular environments.
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