Here, small angle X-ray scattering (SAXS) measurements of complexes of VopF with actin and structural modeling reveal that VopF stabilizes linear actin-strings that differ from canonical actin filament architectures but represent non-polymerizable sequestered forms of actin.
Therefore, consonants that are rendered word-final due to vowel lenition are predicted to differ from canonical word-final consonants in terms of various acoustic parameters.
Variants differ from canonical histones in their protein-protein interactions, localization in chromatin, number and types of PTMs, nucleosome stability, and tissue-specific expression profiles [ 5].
Adhesion class G protein-coupled receptors (aGPCR) form the second largest group of seven-transmembrane-spanning (7TM) receptors whose molecular layout and function differ from canonical 7TM receptors.
In the past decade, variant histones that differ from canonical histones have been recognized to occupy specific genomic regions and to possess distinct regulatory functions.
However, recently non-canonical autophagy pathways were discovered that differ from canonical signaling, as they do not necessarily require the hierarchical action of the ATG proteins and protein complexes.
The small RNAs aligning to extended 3'UTRs in somatic tissues differ from canonical piRNAs: they are shorter, lack the predominant 5' uracil, and much less abundant than their testis counterparts.
The resulting proteins differ from canonical, full-length p53 protein, by truncation of a variable portion of the N-terminus (ΔN isoforms) and by alternative C-terminal portions (C-terminal isoforms).
However, the mammalian F-BAR Slit-Robo GTPase activating proteins (SRGAPs) differ from canonical F-BAR proteins, as they induce negative curvature (i.e., curvature away from the protein-decorated leaflet of the membrane), forming invaginations into liposomes in vitro and filopodia-like protrusions in cultured cells.
Hence, an improvement for our procedure, that would account for this case as well as for those unmapped proteins that differ from canonical sequences only by few amino acids, would be to use direct sequence comparison to find the closest valid reference sequence.
