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The ancestral gene, named AncCR (for ancestral corticoid receptor), was not found in jawless fish such as lampreys but did exist in cartilaginous fish and in bony fish and their descendants the tetrapods (four-limbed vertebrates, including humans).
We identify " novel CPs" as those that exist in the current ancestor/species but did not exist in previous ancestors, and " lost CPs" as those that do not exist in the current ancestor/species but did exist in the previous ancestor.
We identify " novel CPs" as those that exist in the current ancestor/species but did not exist in previous ancestors and " lost CPs" are defined as those that exist in the current ancestor/species but did exist in the previous ancestor.
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