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A plausible interpretation for these findings is that the trans-splicing machinery generates a low, but detectable number of events in which the mini-exon is misplaced.
Interestingly, Y27632 treatment even in osteogenic differentiation medium resulted in a small but detectable number of cells that produced lipid droplets staining positive for Oil Red O (supplementary material Fig. S1).
These lymphocytes were defined as non-switched (IgM+ IgD+) memory B cells based on the findings that they express the putatively memory B cell marker CD27 [ 2], and harbor IGV genes exhibiting a low but detectable number of somatic mutations, an event classically restricted to post-germinal center (GC) memory B cells [ 2, 9].
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However, leukocytes of old air-breathing mice yielded low, but detectable numbers of CFU-Fs (1.0 ± 0.8 CFU-F/1 × 10 leukocytes); the number of CFU-Fs did not change by HBO (p > 0.05).
Microparticles derived from platelets (CD61) and erythrocytes (glycophorin A) were below detection level (less than 10/l) in synovial fluid from all patients, except in one RA patient who had a low but detectable number (1.7 × 10/l) of platelet-derived microparticles.
Let us set Nc = 109 as a critical detectable number of cells for a tumor detection.
Only one of these SNVs however was also detected in the according blood samples, suggesting much variation in the detectable number of differences, also depending on the tissue type sequenced.
Figure 2a reveals that the minimum detectable number of LNCaP cells (MDC) incubated in suspension for which PET detection probability is just 50% is 8 × 103, 2.7 × 104, 5 × 104, and 1 × 105 at 0, 100, 250, and 500 Bq/ml background levels, respectively.
And no previous particle accelerators were powerful enough to produce a reliably detectable number of Higgs bosons, which are predicted to have a mass between 114 GeV and 184 GeV.
Thus, even coupled with some employment reductions, living wages can lift a detectable number of families above the poverty line.
Based on a previous study [10], it was expected that not all baseline microbiological samples would yield a detectable number of cultivable bacteria ([10], 19 out of 79 = 24% of samples showed no bacterial growth).
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