These different foraging strategies are associated with subtle but consistent differences in craniofacial architecture in the lateral view, with LF possessing a more "extreme" biting morphology characterized by relatively shorter jaws and a steeper profile on average compared to TRC (Cooper et al. 2010; Parsons et al. 2014).
Timing explains much of the difference in interpretation -- Romney and Paul have both gained significantly since early December, with less change apparent in the last week -- although the subtle but consistent differences in the findings highlight a big inherent challenge of polling the Iowa caucuses.
However, differences in gene expression between neuronal cell types are likely to be relatively small, so both the experimental protocol and the subsequent analysis had to be optimized to detect small, but consistent, differences in gene expression.
Figure 1 shows that after 24 hours few but consistent differences in cell morphology were already appreciable in treated cells, which started to elongate in comparison with control cells.
Specifically, the small but consistent differences in DNase sensitivity and H3K3me3 signal we observed for the 30% lowest peaks are consistent with distinct sub-populations within the data.
Small but consistent differences in DNase sensitivity and H3K4me3 signal together with low TF peaks indicate that these TF binding events occur within small but consistent subpopulations of the cell cultures.
This study shows that lifetime fitness is the product of many parts and that small, statistically insignificant but consistent differences in these parts can add up to large differences over the course of a life cycle.
The above-mentioned Western blot analysis revealed slight but consistent differences in migration distance of the putative tetramers/oligomers of many mutant proteins in comparison to the wild-type CBS tetramer (see Fig. 2).
However, despite considerable overlap in altered brain activation across symptom dimensions of OCD, there are subtle, but consistent, differences in activation patterns that may impact on treatment strategy and outcome.
