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The synthetic data example shows small but consistent changes in the transfer functions associated with hydraulic stimulation, with grids of Mohr circles introduced as a useful diagnostic tool for visualising the extent of fluid movement.
Whereas conventional analysis techniques promise great sensitivity in detecting genes with subtle but consistent changes in expression, Messina offers the opportunity to identify those with inconsistent differences.
Rapid change of the bath solution from a Na+-rich solution (B2) to a Li+-rich solution (B4) led to small but consistent changes in the current.
Decidualization elicited modest but consistent changes in the expression of several transcripts, including up-regulation of BMAL1 mRNA levels and down-regulation of CRY1 and CRY2 expression (Fig. 2 A ).
These observations imply that low but consistent changes in expression of a large number of genes can provide sufficient statistical resolution to be informative regarding any organ pathology that may be present.
Subtle, but consistent, changes in environmental cues perceived by A. thaliana are amplified through THERM QTL alleles, affecting downstream signaling cascades that result in a qualitative shift from overwintering to rapid cycling, which would have dramatic effects on reproduction.
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The number of Differentially Methylated Probes (DMPs) might be fractional to the full set of > 470,000 probes but it is possible that there is a small but consistent change in methylation signature due to differences in preparation methods and/or storage conditions between the two sample types.
Alterations in CEC numbers is likely to reflect vascular damage (Strijbos et al, 2008), but no consistent changes in CEC numbers could be seen, either during therapy or between the two sunitinib doses explored.
Administration of MBP to co-twin marmosets neonatally for 2 weeks did not suppress blood levels of testosterone, but there were consistent changes in Leydig cell volume per testis due to increased Leydig cell number and/or size (increased cytoplasmic volume); similar changes were observed in marmosets treated with DBP.
The present characterization of the phenotype of these cell lines derived from natural squamous intraepithelial lesions shows an association between simple epithelial-type keratin expression and progressive changes in growth and morphology, but fails to demonstrate consistent changes in the expression of cell cycle regulatory proteins studied in parallel with progression.
Four generations of serial passage of each of two strains of S. solani on each of 11 clover taxa (22 separate lineages) led to significant increases in infection rates, but there were no consistent changes in virulence (i.e., disease impacts on the host) (Fig. 2).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com