Identifying non-conserved miRNAs but conserved Dicer and Argonaute proteins is in line with the hypothesis that the protein machinery to process miRNAs has a common evolutionary origin, whereas the set of generated miRNAs is lineage-specific [ 19].
Their NifE-related components (CLM_0808 and Clos_0313) contain the three conserved P cluster ligands, but conserved Cys residues are not present in the NifN-like components (CLM_0809 and Clos_0314).
Thus, both mutated and conserved sites are rich in non-functional sites, but conserved sites are almost two times richer in selected sites.
To answer this, we compare the conservation level of CNSs that have been lost in mouse but conserved among human, marmoset, and chicken (see table 1).
The crystal structures of two human type I IFN ternary signaling complexes containing IFNα2 and IFNω reveal recognition modes and heterotrimeric architectures that are unique among the cytokine receptor superfamily but conserved between different type I IFNs.
This suggests different but conserved functions for mammalian Xinα and Xinβ.
Positions 213, 244, 461, 595, 786, and 811 were different between, but conserved within the eastern and western topotypes (Figure 2).
Similar features were observed in the alignment with the S. agalactiae genome but conserved regions were reduced in size and symmetry (not shown).
The protein OE3943R, uncharacterized but conserved in archaea, was found to be phosphorylated on Thr13 and Thr18 (conserved in archaea) close to its N-terminus.
If a possible function was still unclear, we used the BLAST search results to classify the gene as either unique to Drosophila (and closely related species (as far as mosquito)) or unknown but conserved among a range of species.
Sequence analyses of various insect proteins identified a cysteine residue that is absent in mammalian [7] [9] and avian [8], [10] AChEs but conserved in the AChEs of aphids and several other insects [7] [9], [11].
