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In combination, these studies suggest antiherpesvirus treatments such as ganciclovir (1) and valganciclovir (2) aid in the treatment of KS but are not efficacious enough to be used as monotherapies.
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Posterolateral visualization directly with the camera and via the anterolateral portal is efficient and associated with minimal morbidity but was not efficacious in the cohort evaluated.Level of Evidence:Level II.
Similarly, calcium channel blockers can reduce contraction amplitude in normal subjects and patients with high-amplitude contractions, but these agents are not efficacious in relieving symptoms and produced significant side effects in the controlled clinical trials.141, 142 Therefore, it is clear that therapies other than smooth muscle relaxants are required in the treatment of esophageal pain.
Glucocorticosteroids are not efficacious.
The treatment of migraine attacks with aura by triptans is difficult since triptans most probably are not efficacious when taken during the aura phase.
Segal (2009) argues that being a belief and being a desire are dispositional properties, and that dispositional properties are not efficacious.
Prevention strategies using tamoxifen are not efficacious for these tumors.
As mentioned, resident microglial cells surrounding Aβ plaques are not efficacious in degrading Aβ.
However, these drugs are not efficacious in several epilepsy syndromes and there are tolerability issues associated with their use.
Similarly, codeine and its derivatives used widely for cough in adults are not efficacious in children and are contraindicated in young children.
One potential hypothesis is that 9cRA or its metabolites are not efficacious in highly proliferating cell systems, like PEC stimulated by the above hormones.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com