Results: After incubation in medium from hypoxic cytotrophoblasts, arterial segments were more responsive to phenylephrine and to potassium-induced constriction but were less responsive to methacholine, and the vasomotor activity was increased compared with that found in vessels incubated in control medium.
Rannou et al. [ 46] showed that AF is stimulated by IL-1β in vitro to produce factors implicated in degenerative processes but is less responsive to IL-1β-induced apoptosis than articular chondrocytes.
Larvae were attracted to a blend of these compounds, but were less responsive to this mixture than to a presentation of each molecule alone, which suggests an interaction between the two pheromones.
In general, the EQ-5D Index and VAS showed good reliability and responsiveness in comparison to other generic measures such as the SF-12 but were less responsive than disease-specific measures such as the KCCQ [ 26, 27].
In particular, the FACT-P was responsive in both phase 3 registration studies for abiraterone as well as phase 3 studies for enzalutamide and docetaxel for patients with mCRPC but was less responsive in the registration study for radium Ra 223 dichloride described in the SmPC [[ 7],[ 28],[ 29],[ 34]].
Generic measures cover a broad range of HRQoL dimensions in a single instrument and are applicable in a wide variety of populations, but they are less responsive than specific tools that focus on a particular disease or symptom.
Thus, they are less responsive at lower contrasts, but their responses do not saturate at higher contrasts.
The infection can be treated with antimicrobial medications, but people with serious complications are less responsive to the drugs.
Negative symptoms are deficits of normal emotional responses or of other thought processes, and are less responsive to medication.
