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A successful tissue engineering approach would require not only induction of chondrogenic differentiation, but also suppression of subsequent endochondral ossification and chondrocyte dedifferentiation.
Moreover, CD44 expression in HNSCCs is indicative of not only a stem-cell-like phenotype, but also suppression of T-cell-mediated immunity and induction of PD-L1 expression124.
This interaction triggers not only effective clearance of apoptotic cells but also suppression of the inflammatory response [14], [15] or of adaptive immunity [16], thus limiting local tissue responses and normally leading to a quiet cell removal [13].
Accordingly, induction of LDLR levels in-vitro requires not only the absence of sterols from the culture medium, but also suppression of cellular cholesterol synthesis (see Section 5.2).
Transcriptome analysis of vhl mutant embryos detected activation of key hypoxia response genes seen in human cell models of hypoxia, but also suppression of many genes primarily involved in lipid processing.
Furthermore, knock-down of Rab1, required for ER-to-Golgi transport in the secretory pathway, caused not just abundant intracellular Drs-GFP retention in Toll 10B adipocytes, but also suppression of PM excess, implicating membrane input from the secretory pathway in PM overgrowth.
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60 This benefit is attributed not only to a direct cytotoxic effect on cancer epithelial cells, but also the suppression of pathologic osteoblast and osteoclast activities (ie, suppression of the chain of events).
"It is a show of political power, but also a suppression of political protest.
On the other hand, doped N element is conducive not only to the absorption of visible light due to narrowed band gap, but also to suppression of charge recombination.
Therefore, in terms of not only producing a sufficient number of pure chondrocytes but also the suppression of cellular dedifferentiation, it is important that the spherical conformation be maintained in suspension culture.
In cooperation with other genes known to be expressed in the developing sensory neurons and hair cells [3], [4], [5], [74], [75], Neurod1 may achieve neuronal differentiation not only through upregulation of appropriate downstream target genes [62] but also through suppression of other bHLH genes that mediate other states of cellular differentiation such as Neurog1 [69] or Atoh1 [26].
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