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The circadian clock coordinates behavior and metabolism into rhythms not only in the central hypothalamus but also in peripheral tissues (Marcheva et al., 2010; Vollmers et al., 2009).
The receptor CB1 is primarily expressed in the central nervous systems (CNS), but also in peripheral tissues and on immune cells [7].
These alterations could occur, not only in target organs/tissues such as fetal lung or the immune system [11], but also in peripheral tissues such as fetal circulating white blood cells and placental tissues, thus providing opportunities to discover and develop highly sensitive and specific, minimally invasive biomarkers for exposure assessments or clinical indications [17].
We initially identified isoforms of human NET (hNET) and DAT (hDAT) as counterparts of the monkey NET variant missing exon 6, in various tissues, since both DAT and NET are known to exist not only in the central nervous system but also in peripheral tissues, e.g. lymphocytes and gut for DAT [13], [14] and placenta for NET [15].
These receptors are present in the central nervous system but also in peripheral tissues.
COMT is constitutively expressed mainly in brain, liver and kidney, but also in peripheral tissue, including the epithelial cells in the ducti and lobuli of normal mammary.
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In this paper, we report the expression of WNT7A in normal peripheral T-lymphocytes and strongly reduced WNT7A expression, not only in leukemia-derived cell lines, but also in the peripheral blood cells of patients with leukemia.
Transmissible spongiform encephalopathies (TSEs) are characterised by accumulation of an abnormal isoform of prion protein (PrPsc), mainly in the brain but also in various peripheral tissues.
When the bronchi are thickened, they are clearly delineated with tomosynthesis, not only centrally, but also in the peripheral lung (Figs. 4 and 5).
It is interesting to note that pain relief exceeds the effect of local anesthetic solution in blockades performed not only in AN but also in other peripheral nerve blocks.
All these results show that PACAP has protective effects in ischemic injuries not only in the nervous system, but also in several peripheral organs suggesting a general anti-ischemic protective role of this neuropeptide.
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