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It is very important to verify that this phenomenon occurs not only in a single cell type, but also in multiple cell models.

Kunitz domains appear not only in single-domain proteins such as the paradigmatic member of the family, bovine pancreatic trypsin inhibitor (BPTI) [3], but also in multiple tandem repeats (e.g., the three consecutive domains that build up the major inhibitor of the coagulation cascade, tissue factor pathway inhibitor/TFPI) [4].

Peripheral nerve lesions have been used for evaluating injury-related neural plasticity not only in motoneurons but also in multiple brain structures.

ChIP-seq data is being rapidly generated not only for many TFs and epigenetic marks, but also in multiple conditions, tissues, cell types, and individuals.

Altogether, these results suggest that aho-3(nj15) mutants have abnormalities not only in thermotactic plasticity but also in multiple complex behaviors.

The EQ-5D has been shown to be both reliable and valid in adult patients with GH deficiency but also in multiple musculoskeletal diseases [ 16].

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These data show that not only in the acute and relapsing stage of the disease but also in progressive multiple sclerosis (SPMS and PPMS), axonal injury is associated with inflammation.

Importantly, linaclotide showed efficacy not only in terms of constipation relief but also in terms of multiple other abdominal and bowel symptoms associated with IBS-C, including abdominal pain and discomfort.

Therapeutic targeting of FAK kinase activity using small-molecule inhibitors will inhibit FAK signaling not only in tumor cells, but also potentially in multiple host cell types.

Binding promiscuity is not only observed in drugs binding multiple HLA-variants, but also in HLA-variants binding multiple drugs.

Since deficits in PPI are not specific to schizophrenia or ASD, but also shown in multiple neuropsychiatric disorders including bipolar disorder (51), a certain form of attention deficit hyperactivity disorder (52) and obsessive-compulsive disorder (OCD) (53), it would be interesting to explore the possibility that FABP7 could be a common contributor to all these disorders.

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