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Undoubtedly, some of the miRNAs identified will have roles not only in mosquito development, but also in mediating viral infection in the mosquito host.
Elevated levels of FGF in cartilage have been associated with not only arthritic disease leading to joint destruction [ 22], but also in mediating cartilage regeneration [ 23].
Undoubtedly, some of the miRNAs identified here will have roles not only in mosquito development, like their Drosophila counterparts, but also in mediating viral infection in the mosquito host.
CCA1 and LHY are important regulators of circadian rhythm in Arabidopsis, not only involved in regulating the expression of TOC1, but also in mediating light input to the core oscillator [ 10- 12].
Further, following terrorist attacks, good communication with the public is essential not only to reduce acute morbidity and mortality but also in mediating the social and psychological impact of terrorist attacks [ 3].
A challenge for future studies will be to functionally dissect the molecular mechanisms by which some of these isoform-specific activities are involved in maintenance not only of epithelial barriers, but also in mediating epithelial-mesenchymal crosstalk during development and maintaining other properties of epithelial cells.
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OB-domains are functionally diverse, as they are involved in binding oligonucleotides, oligosaccharides, or metal ions and also in mediating protein−protein interactions (18, 19).
The production of the peroxynitrite and the nitrosylation of proteins might play a role in bacterial killing and also in mediating host injury [ 38, 39].
The brain's GABA-mediated (i.e., GABAergic) signaling system has been implicated in alcohol's actions on the brain and also in mediating a genetic predisposition toward alcoholism (Enoch 2008).
The interaction of chemerin with ChemR23 is assumed to play an important role not only in the migration of macrophages and DCs to the sites of inflammation but also in the mediating inflammatory signaling to articular chondrocytes and endothelial cells.
SLCO1B3 (organic anion transporting polypeptide 1B3; also known as Organic anion transporting polypeptide 1B3 or OATP1B3) is a member of membrane influx transporters that normally regulate the uptake of endogenous compounds, but which are also important in mediating drug absorption [reviewed in (Kalliokoski and Niemi 2009)].
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