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Since only a readily available short synthetic DNA fragment is needed for constructing this novel reporter-based siRNA validation system, this system not only provides a powerful strategy for screening highly effective siRNAs but also implicates in the use of RNAi for studying novel gene function in mammals.
This not only demonstrates a true prognostic value for BCAR3 but also implicates that loss of BCAR3 expression may be involved in breast cancer progression.
Structural stability allows more complex and fragile systems with more specific response but also implicates a slower adaptation to external conditions.
HSP70 as one of major molecular chaperones not only participates in the cellular protein quality control and degradation systems, but also implicates the neuroprotective response to pathological manifestations of AD [ 6, 11, 32, 48].
Almost exclusive expression of the V2R protein in renal collecting ducts warrants specificity and safety of the drug but also implicates that extrarenal PKD manifestations will not be targeted.
According to Flögel et al (2005), lack of Mb in the heart of knockout mice leads to a biochemical shift in cardiac substrate utilisation from FA to glucose oxidation, which, not only corresponds to an adaptive reduction in O2 consumption for the equimolar production of ATP but also implicates the protein in providing FA substrates for the mitochondrial β-oxidation breakdown in vivo.
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Recent studies not only confirm the association of APOE with longevity in different populations, but also implicate several other pathways that may influence longevity including nitric oxide production, inflammation, immunity, and DNA damage response and repair.
Our studies not only pave a way to the understanding of pharmacological mechanisms of Gefitinib, but also implicate for the necessity to prescreen p53 expression level before clinical application of Gefitinib in human cancer therapy.
In summary, these phenomena not only demonstrate a dynein-dynactin-independent mechanism of selective transport that preferentially targets Dscam[TM1]-containing vesicles to dendrites, but also implicate the involvement of retrograde axonal transport in preventing accumulation of Dscam[TM1] in axons.
Thus, these studies not only substantially broaden our understanding of the complex mechanisms underlying the pathogenesis of CCA but also implicate potential new interventional and therapeutic strategies.
In multiphasic CT, comparisons between attenuation coefficients allow a semi-quantitative indicator for contrast agent enhancement but also implicate increased radiation dose due to the additional unenhanced scan.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com