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In contrast, α-TEA treatment in vitro resulted in significant induction of apoptosis but also cooperated with trastuzumab to further decrease activated AKT levels, providing a mechanism of the enhanced tumor cell reduction in the α-TEA+trastuzumab combination treatment.
We showed that ectopic Ben/dUev1a expression not only induced MMP1 upregulation and cell migration but also cooperated with Ras V12 to promote tumor growth and invasion, suggesting that Ben and dUev1a are candidate proto-oncogenes.
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The preprotein translocases that reside on the mitochondrial membranes not only function during organelle biogenesis to deliver newly synthesized proteins to their final mitochondrial destination but also cooperate with numerous other mitochondrial protein complexes that perform a wide range of functions.
To this end, each node k not only uses its local measurement d k,i and input vector u k,i but also cooperates with its closest neighbors for updating its local estimate w k,i.
Therefore, HIF1α not only counteracts the MYC-mediated suppression of mitochondrial biogenesis by reducing mitochondrial mass and function, but also cooperates with MYC to promote aerobic glycolysis by induction of HK2 and PDK1 [133].
Therefore, the stimulatory effects of the oestrogen receptor can directly increase transcription from Brn-3b gene promoter but also cooperates with Brn-3b to further enhance expression.
This idea is useful to separate a complicated network into many simpler ones, which can work independently but also cooperate with each other.
SYN predominantly uses the ubiquitin-conjugation enzyme 7p (Ubc7p) as an E2 but also cooperates with Ubc6p and Ubc1p in ER-associated degradation [ 9].
NFATc1 is not solely a downstream target of Fos but also cooperates with Fos and Jun proteins to induce osteoclast-specific genes such as tartrate-resistant acid phosphatase or cathepsin K.
Phenotypic analysis of this strain revealed remarkable fitness recovery indicating that mutations, which have accumulated in the strain, are not only tolerated but also cooperate to achieve long-term population survival in the absence of DOG-1 and MDF-1.
More importantly, it has been reported that PLD not only suppresses apoptosis in the cells with elevated tyrosine kinase activity but also cooperates with tyrosine kinases to contribute to progressing to a malignant phenotypes [ 27, 28].
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