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Therefore, the VX-809-mediated correction of ΔF508 CFTR that we observed was not merely due to localization of more ΔF508 CFTR protein to the plasma membrane, but also attributable to the stabilization of the protein at the plasma membrane via potentiation of interactions with NHERF1.
This wide variability in the sensitivity may very well be due to the methods employed, but also attributable to differences in the sampling techniques, or the clinical and laboratory criteria applied for defining the presence or absence of the disease [ 7].
This difference is partly attributable to the effect of discounting, where we in our study use a 3% discount rate for effects, compared to the discount rate of 1.5% applied by van den Berg et al., but also attributable differences in the baseline population.
Assuming a similar growth property of autologously transplanted CSCs, it is reasonable to interpret that the therapeutic effect, lasting for more than two years in the SCIPIO trial, was not only owing to the multiplication of the regenerated myocytes but also attributable to the maturation of each differentiated cell: namely, "cellular reverse remodeling".
A major concern with the use of DNMT inhibitors is their potential to induce genomic rearrangements, traditionally attributed to global demethylation based on cytogenetic observations made in the immunodeficiency, centromeric region instability, facial anomalies (ICF) syndrome [ 11] but also attributable to the formation of DNMT1 adducts in cells treated by 5-aza-CdR [ 12].
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This is the result partly of cooler recent vintages, leading to more minerality and higher acidity, but is also attributable to many producers choosing to dial back on the new oak and to lower ripeness levels by picking earlier than in years past.
The exclusion of ozone is partly because of past emphasis on the power sector, where SO2 and PM receive greater attention, but is also attributable to limitations in the atmospheric models used in previous studies (Li et al. 2004).
There is a growing body of evidence suggesting that many youth and adult health outcomes are not merely the result of the differential distribution of individual-level risk factors, but are also attributable to aspects of the social and economic environment (i.e., context) [ 1- 7].
But it was also attributable to a decrease in job losses in weak areas, including financial activities.
But some is also attributable to the success of David McCullough's current best-selling biography of John Adams, said Caroline Keinath, the park's deputy superintendent, who recounted a recent conversation with a woman who explained her reasons for visiting the site: "I wanted to be reminded of the principles our forefathers fought for".
The other absorption bands, and in particular those at 3360, 2926, 2855, 1709, 1451, 1382, 1170, 1038 and 887 cm−1could be ascribable to the resinous varnish already identified on the fragment surfaces, but could be also attributable to the cellulose of the wooden substrate under the decoration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com