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Anything but a substantial increase would have been quite a disappointment.
When the HIV prevalence model fits of the three calendar periods are compared (Fig. 2), we observe virtually no change of HIV prevalence in younger women aged 15 24 years, but a substantial increase of HIV prevalence in women aged 30 49 years in 2009 2011 compared with the two earlier periods.
In the thymus, we noted that both DKO and TKO chimeras showed a significant decrease in double positive (DP) thymocytes (CD4+CD8+), but a substantial increase in single positive (CD4+CD8− and CD4−CD8+) and double negative (DN) thymocytes (CD4−CD8−) in comparison to WT controls.
Further reduction in recovery times was not seen when all three tandem repeats harboured the mutation corresponding to N1168F in full-length CREBBP (P > 0.05), but a substantial increase in the wild type was seen with the addition of SAHA (2.5 ± 0.1 seconds; P < 0.05).
Overall, only 34% of health workers are employed to work in primary health care facilities; only 5% of posts are currently vacant, but a substantial increase has been recommended for 2016 (from 2209 to 4722), both in primary and secondary care [ 12].
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But a Department of Transportation spokeswoman, Jill Zuckman, said a temporary outage Friday was caused not by too many dealers trying to get onto the system but by a "substantial increase" in online capacity to help the department review transactions and process payments to dealers.
On the other hand, the POSS-coating promoted the reduction of surface roughness, but induced a substantial increase in the water contact angle (WCA), probably due to the modification of the surface chemical nature.
Increasing the WBC count ensures that low-parasitemia cases are not missed, but requires a substantial increase in microscopy time.
The combined application also did not affect T2 at up to 100 nM, but caused a substantial increase at 1,000 nM (>8-fold).
The present standard of care, direct antiviral agents telaprevir and boceprevir, has offered higher sustained virological response rates but with a substantial increase in cost.
In the present study, we found that children with HFMD displayed significant decreases in their peripheral CD3+, CD3+CD4+ and CD3+CD8+ cell subsets, but had a substantial increase in their peripheral CD3−CD19+ cell subset.
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