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For the same network, but a sample size of 20, we obtain a p-value of 0.08638.
"Flexible" second-to-first-stage ratios allow different sample size reassessments for the selected treatment and the control, for example a sample size decrease for the control, but a sample size increase for the selected treatment group.
Statistically, the overall survival in this small series was much higher than predicted by the calculated APACHE II scores of the patients, but a sample size of 10 patients certainly does not allow drawing any conclusions in respect to outcomes.
By keeping confidence intervals narrow we increase the expectation of making accurate statistical inferences, but a sample size of more than 1,300 subjects would be necessary to satisfy this principle.
The calculation of the sample size for an up-and-down method has not been clearly defined, but a sample size of 20 – 40 for each group is generally considered acceptable [ 15].
A justification of the sample size was provided by 58%% of protocols, but a sample size calculation by effect estimation was performed in only 11%% of the NIS; 35 % justified the sample size by the width of a predefined confidence interval and 12 % justified the sample size by simply declaring their sample size as appropriate for answering the study objectives.
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Six excluded studies examined the prevalence of cervical instabilities in RA but had a sample size of less than 100.
The coverage probability of the LT interval is slightly conservative for small sample sizes (coverage probability up to 96%), but for a sample size of 100 or 200 the coverage is independent of the true AUC0 and equals roughly 95%.
Kitabatake (77) found a higher sex ratio among offspring of Japanese radiologists and X-ray technicians, but had a sample size of only 246 births to exposed men (exposed, SR = 1.14; referent group, SR = 1.04).
Thus, it appears that GCs are uniformly distributed across exons, but with a sample size of five GC events, we lack power in our test for a difference in the distribution of GC and CO events.
Another potential application of genomic prediction is rapid-cycle, marker-based recurrent selection in closed populations, like in La Posta Sequía but with a sample size >100, that will serve as sources of inbred lines.
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