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Lallemant and colleagues, using a quantitative PCR approach in saliva, validated MMP1 as a specific marker at 100% but a low specificity of 20% [111].
We found a fairly high sensitivity (72.2%) of ILI for influenza, but a low specificity (48.1%) in keeping with sensitivities of 55.4 86.8% and specifities of 39.3 67% reported elsewhere [ 25, 39, 41, 37].
The presence of vaginal neutrophils diagnosed by saline wet mount had a high sensitivity (90.9%) and negative predictive value (94.5%), but a low specificity (26.3%) and positive predictive value (17.1%) for the diagnosis of upper genital tract infection.
The above method has a very good sensitivity, catching most of the falls, but a low specificity.
In this context, we found a high sensitivity, but a low specificity of 11C choline PET/TAC at software assisted target biopsy.
A fecal calprotectin levels more than 200 µg/g has a good sensibility of 1.0 [0.72–1.0] but a low specificity of 0.64 [0.57–0.71] to predict poor tolerance to enteral feeding.
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Therefore, detection of NDM-producing isolates using ChromID ESBL (aimed do detect ESBL producers) is possible but with a low specificity since the selective agent is a cephalosporin and not a specific carbapenemase substrate (e.g., a carbapenem).
Conclusions: In a region with a high prevalence of pulmonary fungal infection, FDG-PET is sensitive but has a low specificity and NPV for identifying NSCLC.In our study cohort, FDG-PET does not appear to reduce the need for SPN biopsies.
The three miR combination appeared most sensitive for UCC (94.1%), but had a low specificity (51%).
For detection of recurrent disease, T2WI is highly sensitive (90 91%)[ 70, 71 ] but has a low specificity (22 38%).
These have been validated for the assessment of aging patients with hypogonadism (Morley et al 2000; Moore et al 2004) but have a low specificity.
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