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Cav-1 and IGF-IR play independent roles in the regulation of cell growth, adhesion and migration but a functional link between these two proteins has been demonstrated [19], [32].
Aberrant DNA hypermethylation in human cancer has been associated with Polycomb target genes in embryonic stem (ES) cells, but a functional link of the Polycomb-targeted differentiation program to tumorigenesis remains to be established.
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All these data document not only how the endocytosis machinery is recruited and involved in the internalization of L. monocytogenes but also suggest a functional link between E-cadherin endocytosis and the formation of adherens junctions in epithelial cells [ 103].
These ictal observations in reading epilepsy not only support our finding of motor cortex hyperconnectivity, but also suggest a functional link for the often noticed association of reading epilepsy and JME in the same individual, and the recently reported observation of orofacial reflex myocloni triggered by reading and talking in JME (Mayer et al., 2006).
This is not surprising, as synthetic sick or lethal combinations can be used to infer a functional link, but the mechanistic basis for that link often remains obscure.
But investigation of mechanisms that provide a functional link between homocysteine and arterial stiffness might be another fruitful research direction.
Co-occurrence is another way to predict a functional link between genes, but it is particularly hard to use this evidence for functional linking of protein families, especially for those with large number of paralogs.
This suggests that there is a functional link between the anti-proliferative effects and checkpoint function of CHFR.
Ochoa, G. C. et al. A functional link between dynamin and the actin cytoskeleton at podosomes.
These results suggest a functional link between FBP17-dependent membrane tubulation and clathrin-dependent budding.
Martins, L. et al. A functional link between AMPK and orexin mediates the effect of BMP8B on energy balance.
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Justyna Jupowicz-Kozak
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