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Low-dose estrogen progestin (LEP) agents are often used for relieving endometriosis-associated chronic pelvic pain, but a direct effect of LEP on endometriotic lesions remains to be demonstrated.
In addition, the met allele has been associated with abnormal hippocampal neuronal function as well as impaired episodic memory in human subjects, but a direct effect of BDNF alleles on hippocampal processing of memory has not been demonstrated.
It seems likely, from other cases that have been studied in detail, that sumoylation can directly affect protein stability, but a direct effect has not been proven in this case.
Although previous study agree with an effect on immunosuppressive properties of MSCs [ 24], but a direct effect on T cells, rendering them resistant to suppression, cannot be excluded.
The precise mechanism of KGF action is not completely described yet, but a direct effect of KGF on the increase of the Nrf2 activity was proposed [ 8].
Infections may be related to diabetes, but a direct effect of the medication on the occurrence of infections should be considered.
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The effect of progesterone is not mediated by the nucleus but is a direct effect on the cytoplasm.
A mound excavation experiment demonstrated that the positive temperature effect on CH4 emissions was not related to termite movement in and out of a mound but probably a direct effect of temperature on methanogenesis in the termite gut.
Results indicated that vitamin E had no significantly effect on muscle proximate analysis, hematological and immunological parameters of sub-yearling beluga but has a direct effect on growth performance of beluga sturgeon and this vitamin is an essential nutrient required for normal growth in this species.
Those authors stated that the reasons for the differences in survival of S. maltophilia in the various soils were not clear, but supposed a direct effect of nitrate and ammonium contents and pH.
"The bottom line of our research is that laughter not only makes us feel good, but has a direct effect on our blood vessels, and our blood vessels control the likelihood of us developing a heart attack or stroke," Miller says in the video above.
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