In accord with our hypothesis, we demonstrated that QA increases tau phosphorylation and so is likely to be a critical factor involved in NFTs formation and subsequent neuronal death.
A key aspect of our studies is the direct, serial and simultaneous visualization and assessment of both implanted tumor cells and host blood vessels to show that endogenous erythropoietin is a critical factor involved in the attraction of new capillaries to vascularize the expanding tumor mass.
Calcium signaling is a critical factor involved in T cell activation, differentiation and function.
These results suggest that hMYH is a critical factor involved in the interaction between hTopBP1 and hRad9, an important early step in ATR signaling.
Aberrant activation of autocrine TGF-β signaling is a critical factor involved in the maintenance of the fibrotic phenotype of SSc fibroblasts [ 16].
Although mice and pigs overexpressing PCSK9 developed hypercholesterolemia and AS, these animals, unlike humans, do not express CETP, a critical factor involved in lipid transport and AS development.
Transforming growth factor- β (TGF- β) is a regulator of cell cycle progression and is considered a critical factor involved in the late stages of tumourigenesis (Leivonen and Kahari, 2007).
Herein, we discovered that PVF2 is a critical factor involved in age- and oxidative stress-related changes in the number and activity of stem and progenitor cells in the Drosophila midgut.
Our results, using genetic, cell-autonomous control of TGF-β signaling through expression of TβRII, specifically identified TGF-β as a critical factor involved in epithelial migration in the tumor microenvironment.
GSH is an intracellular reductant that plays major roles in catalysis, metabolism and transport, and protects cells against free radicals, peroxides, and other toxic compounds, as it is a critical factor involved in the glutathione system to scavenge hydrogen peroxide and organic hydroperoxides [ 34].
By binding transforming growth factor β, the most critical factor involved in inflammatory fibrosis, HA helps to concentrate and to protect from proteolytic degradation this growth factor [ 47], which could be then released by PH-20.
