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Metformin had no effect on cell numbers but phenformin caused a concentration dependent reduction in cell proliferation with a half maximally inhibitory concentration between 30 and 100 μM (Fig. 5B).
As expected, p53 levels were unchanged in PA-1 and HCT116 cells, but these compounds induced a concentration dependent increase on p53 levels in PA-1/E6 cells.
The present results showed that PM2.5 (50–800 μg/ml) decreased HUVEC viability and increased intracellular generation of ROS and malondialdehyde (MDA) in a concentration dependent manner, but increased HO-1 expression without concentration dependence.
Suramin also antagonised HdP2X currents in a concentration dependent manner but not as strongly as PPADS.
Fibroblasts adhered to both FN preparations in a concentration dependent manner, but with a significantly lower efficiency to PCa FN.
p62 expression was increased by the transfection of p62 expression vector in a concentration dependent manner, but cell viability was not changed (Fig. 6b,c).
PE extract treatment decreased hTERT and hTR mRNA levels in a concentration dependent manner but had no effect on TEP-1 expressions of ZR751 cells.
(a) concentration dependent (b) time dependent.
Quantification showed a concentration dependent inhibition for NC cells.
This metal chelating activity was a concentration dependent.
TBQ decreased SERCA activity in a concentration dependent manner.
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