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Recent mutagenesis experiments using four different proteins revealed that populations subjected to neutral drifts and purifying selection show increased sequence divergence (including that of buried core residues) in enzymatically active proteins when co-expressed with bacterial GroES/L due to the chaperonin's protein folding buffering capacity [17].
The tightly packed buried core of the Greek key provides an appropriate environment for maintaining such relationships and also excludes solvent.
In principle any small hydrophobic residue should suffice in the tightly packed and highly buried core positions, but prolines in particular score well in the helical term (being helix breakers in the most non-helical segment of the protein)[ 32] and are mostly acceptable in the sheet term.
We find, however, from molecular dynamics and accelerated conformational sampling simulations that the Young's modulus of the buried core of the fibril is of the same order as that of a triple helix in aqueous phase.
Since hydrogen bonds involving –OH groups can be formed both in the buried core region (with other polar groups) and ath the exposed protein surface (with solvent molecules), the position of an spH1 H-atoms does not depend on whether the –OH group is buried or not.
Residues in the buried core and residues on the solvent-exposed surfaces were shown to have different substitution patterns due to different selection pressure [ 64].
Similar(54)
Resist the desire to avoid conflict, because burying core disagreements buries marriages.
Defensins are small (~5 kDa) cysteine-rich peptides and consists of a cystine-stabilized αβ fold, in which the buried hydrophobic core is formed by four disulfide bridges that link pairs of the eight conserved cysteines (Cys1 through Cys8).
Onion-like graphenic layers often cover the buried iron cores.
The NASA Juno mission is currently in orbit around the planet trying to determine whether there is a solid rocky/metallic core buried at the centre of the planet.
However, for me, this definition is somewhat defensive and convoluted, burying the core of our field in a flurry of verbiage.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com