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Changes in symptom burden were measured using the MPN-SAF, a validated tool for assessment of symptoms associated with MF.
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To determine whether enzalutamide inhibits androgen-mediated growth in vivo, MCF7 cells constitutively expressing luciferase (MCF7-TGL) were injected into the mammary fat pad of ovariectomized mice implanted with DHT pellets and the tumor burden was measured using luminescent imaging and caliper measurements.
RNA was isolated from infected tissues and B. burgdorferi burden was measured using quantitative PCR.
Care burden is measured using the Caregiving Consequences Inventory [ 45].
Cutaneous tumor burden was measured using the severity-weighted assessment tool (SWAT) and erythroderma scores.
Plaque burden was measured using immunohistochemistry. None of the treatment paradigms reduced Aβ42 or Aβ40.
In this study, economic burden was measured using the methodology outlined in previous studies [ 19, 20].
The morbidity burden was measured using the number of Ambulatory Diagnosis Groups (ADG) provided by the Johns Hopkins Adjusted Clinical Groups ACG Systemem.
When tumor burden was measured using callipers, the tumors from 267/Dt-treated mice were significantly smaller compared with all other treatment groups, including mice treated with Dt alone, (P < 0.05; Figure 8j).
Physical symptom burden was measured using (f) the physical dimension score of the Sickness Impact Profile (SIP), covering three scales, i.e., Body Care and Movement, Ambulation, and Mobility [ 28].
The main dependent variable, experienced care-giver burden, was measured using an extended version of the Self-Perceived Pressure from Informal Care Scale (Pot, Van Dyck and Deeg 1995; Timmermans et al. 2001).
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