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Symptom prevalence, symptom experience and symptom burden were assessed using the Memorial Symptom Assessment Scale (MSAS) [ 15].
SLE epidemiology and burden were assessed using the best published international and national evidences and efficacy and safety of belimumab were synthesized using clinical data.
Correlations between pathology and bacterial burden were assessed using linear regression analysis, whereas the non-parametric Spearman rank test was used to analyze correlations between IFN-γ responses (ΔOD450) and post-mortem data.
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Headache-attributed burden was assessed using the Migraine Disability Assessment (MIDAS) questionnaire [10], recording the numbers of lost days of school or paid work, household work and family, social or leisure activities during the previous 3 months because of headache.
Carer burden is assessed using the Zarit Burden Inventory [ 40].
Caregiver burden was assessed using the Caregiver Burden Scale.
Caregiver burden was assessed using the Zarit scale [ 16].
26 Comorbidity burden was assessed using the Charlson Comorbidity Index.
Bacterial burden was assessed using quantitative microbiologic cultures of contaminated bone.
Small vessel disease burden was assessed using whole brain white matter hyperintensity (WMH) volumes [ 25].
Disease burden was assessed using the Newcastle Mitochondrial Disease Adult Scale NMDASS), a validated scoring system.
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