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To determine whether enzalutamide inhibits androgen-mediated growth in vivo, MCF7 cells constitutively expressing luciferase (MCF7-TGL) were injected into the mammary fat pad of ovariectomized mice implanted with DHT pellets and the tumor burden was measured using luminescent imaging and caliper measurements.
RNA was isolated from infected tissues and B. burgdorferi burden was measured using quantitative PCR.
Cutaneous tumor burden was measured using the severity-weighted assessment tool (SWAT) and erythroderma scores.
Plaque burden was measured using immunohistochemistry. None of the treatment paradigms reduced Aβ42 or Aβ40.
In this study, economic burden was measured using the methodology outlined in previous studies [ 19, 20].
The morbidity burden was measured using the number of Ambulatory Diagnosis Groups (ADG) provided by the Johns Hopkins Adjusted Clinical Groups ACG Systemem.
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Care burden is measured using the Caregiving Consequences Inventory [ 45].
Changes in symptom burden were measured using the MPN-SAF, a validated tool for assessment of symptoms associated with MF.
Burden of disease was measured using the MIDAS Questionnaire.
Similar results were found when the burden of care was measured using the Omega score.
The burden of care was measured using the Caregiver Strain Index, satisfaction with physiotherapy was assessed using the modified Medrisk satisfaction with physiotherapy services questionnaire and compliance was measured as the proportion met of the scheduled appointments.
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