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We aged out cohorts of these mice to 13 weeks of age, and quantified both tumor burden (volume) and tumor number.
Table 1 shows that latency increased significantly, multiplicity decreased, and tumour burden (volume) decreased significantly following combination treatment with the lower doses of AFPep in combination with Tam.
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However, significant relationships between tumor burden (tumor volume) and prognosis have been reported for tumor volume based on MRI [ 10].
This study examined the effects of our lead compound, MBC-11 (the anhydride formed between arabinocytidine (AraC -5′-phosphate AraC -5′-phosphaten bone tumor burden, bone volume, femur bone minerAraC -5′-phosphateand ovetidronateival using twondistinct mouse models of TIbonetumorT1/luc burden cancer and the KAS-6/1-MIP1α multiple myeloma models.
Statistical analysis was performed by analysis of variance for the tumor burden (tumor volume).
Mice injected with 5 × 105 MDA-MB 231 F3 cells showed a 43-fold greater lung tumor burden, by volume, than mice injected with 5 × 105 parental cells.
Furthermore, by enabling analysis of tumor burden, bone volume and cell number over time, the results from this modeling provide important insights into the biology behind the clinical response to bortezomib which cannot be obtained from current in vivo studies.
The antigen sink, which depends on several parameters such as tumour burden, spleen volume and amount of circulating B-lymphocytes, plays a key role in the amount of rituximab needed to ensure adequate serum levels (effective half-life) of the radioconjugate.
The correlation of lung burden, expressed as mass, volume, and surface area, and neutrophil (PMN) counts in BALF as parameter for biological effects is presented in Fig. 7 (Table S9).
From day 1 4 post-inoculation of the cells, we observed a rapid increase of tumor burden to a volume of 50 mm3 (Fig. 3a).
Tumor burden and tumor volume were monitored in vivo over time by quantitation of photon emission using Xenogen IVIS 50 and standard external caliper measurement, respectively.
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