Sentence examples for burden testing from inspiring English sources

Thus, in this study, we evaluated, in a group of newly diagnosed type 2 diabetic patients, the effect of ASA on endothelium-dependent vasodilation and oxidative stress burden, testing the hypothesis that ASA administration (100 mg/daily) in primary prevention is able to increase the oxidation parameters leading to endothelial dysfunction.

One such approach is gene-based burden testing, in which the aggregate frequency of "qualifying variants" is compared between case and control subjects for each gene.

Our results suggest that moderate incomplete penetrance is not an obstacle in this gene-based burden testing approach but that dominant disorders with high locus heterogeneity will require large sample sizes.

These findings were observed in two large studies of the general population comprising >40,000 individuals by applying a series of statistical analyses including Cox regression, logistic regression, haplotype association testing, and burden testing of rare variants.

In a gene-based analysis of rare coding variants (MAF <5%), we performed both nonburden testing (optimal sequence kernel association test (SKAT-O)) [ 26] and burden testing (SCORE-seq) [ 27, 28].

Burden testing for rare variants (21) was performed in two ways: 1) collapsing rare variants with minor allele frequencies <1% and 2) collapsing rare variants that were experimentally verified to be functional.

Will the Court's conservatives — who appear to have, with the addition of Anthony Kennedy, a one-vote majority on this issue — define the "undue burden" test into meaninglessness?

"Applying the substantial burden test requires courts to distinguish important from unimportant religious beliefs, a task for which we have already explained courts are particularly ill-suited," Sotomayor wrote, before applying the test anyhow.

In my dissent in Casey, I wrote that the "undue burden" test made law by the joint opinion created a standard that was "as doubtful in application as it is unprincipled in origin," "hopelessly unworkable in practice," "ultimately standardless".

I have joined Justice Thomas's dissent because I agree that today's decision is an "unprecedented expansion" of our prior cases, "is not mandated" by Casey's "undue burden" test, and can even be called (though this pushes me to the limit of my belief) "obviously irreconcilable with Casey's explication of what its undue-burden standard requires".

"Because the undue burden test requires an assessment of the difficulty of obtaining abortion services, whether in a woman's own state or a neighboring state, and because neither the district court nor the majority has undertaken this assessment, I respectfully dissent," Garza wrote.