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Treatment should be guided by a multidisciplinary approach and includes surgery (ventriculo-peritoneal shunt or Ommaya reservoir placement), radiation therapy to high burden sites and both intrathecal and systemic chemotherapy [37].
Three patients had 4 or more tumor burden sites, including 1 patient with 6 sites of metastatic disease.
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Challenges to testing of biomarkers in the phase I population include a highly heterogeneous population with a mixture of tumour types, heavy pre-treatment burden, multiple sites of disease likely to be molecularly heterogeneous, and varied life expectancy (Carden et al, 2010).
Officials with the West Virginia Division of Culture and History said that they had fielded calls about the care of the Hatfield Family Cemetery but that the burden of site upkeep fell to the property owner.
Networks develop standardized processes for trial conduct (including performance management) that increase the speed and predictability of trial conduct while reducing burdens on sites, sponsors, and intermediaries.
The FCC is investigating how to reduce the burden of siting requirements, and one option is to exempt from review the kinds of small cells that are at the heart of 5G.
The revised plan results in fewer logistical and financial burdens for sites, should continue to provide comprehensive data quality monitoring, and could potentially prove more cost-effective, although without accurate comparators, this assertion remains speculative.
Similarly, only 1/4 of SARI cases treated at a SARI burden study site.
The CRAs also suggested a central CRA who can take over some of the regulatory burdens from sites.
The estimated proportion of SARI cases that sought healthcare within the last year at a SARI burden study site was 25%.
The observation that Sr transfer only ranged from 0.29 to 0.40 μg despite a 10-fold range in total body burdens between sites suggests that the upper limit of Sr transfer to eggs may have been approached.
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CEO of Professional Science Editing for Scientists @ prosciediting.com