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Barriers clustered into four groups: lack of resources, administrative burden, relevance to the research, and lack of interest.
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The burden has fallen on the N.C.A.A. to prove its worth and relevance to players.
Considering patient burden and relevance, the instrument captures all core symptom and impact domains.
This increased burden demonstrates the relevance of CNVs in susceptibility to this early-onset neurodevelopmental condition.
Minimising respondent burden and maximising relevance (e.g. to diabetes type/treatment) were crucial considerations.
Others have also identified likelihood to influence change in practice, relevance, burden of illness, and the potential for significant benefit and harm as factors to consider when selecting a guideline topic [ 3].
Evidence that donepezil may lessen caregiver burden has some relevance to economic assessments of donepezil, which require many factors to be taken into account including costs met by unpaid caregivers.
A symptom burden of potential clinical relevance was defined as a sum total ≥11 on each scale [ 10].
We selected conditions based on their clinical relevance and burden, both in terms of cost and outcome (e.g. attributable deaths) as described in previous literature [ 1- 4, 24, 39, 40].
However, we note that this framing of the problem shifts the burden of determining biological relevance onto the quality of the simulator, which currently emulates some, but not all, known evolutionary processes.
But at a moment when big, dumb thrillers like "The Sum of All Fears" find themselves suddenly burdened with expectations of relevance, the utter and systematic irrelevance of "The Bourne Identity" to anything currently or formerly happening in the world comes as something of a relief.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com